adm-4 Disintegrin and metalloproteinase domain-containing protein 17 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adm-4
Official Full Name: Disintegrin and metalloproteinase domain-containing protein 17 homolog
Primary source: WormBase:WBGene00000075
Locus tag: CELE_ZK154.7
See related: AllianceGenome:WB:WBGene00000075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloendopeptidase activity. Involved in Notch signaling pathway and cell fate specification. Predicted to be active in plasma membrane. Is expressed in several structures, including gonad; intestine; pharynx; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adm-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (7794875..7798298, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The metalloprotease ADM-4/ADAM17 promotes axonal repair.
Title: The metalloprotease ADM-4/ADAM17 promotes axonal repair.
Sup-17 and adm-4 are functionally redundant for at least a subset of LIN-12/Notch-mediated cell fate decisions in C. elegans.
Title: Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R03G5.5 (e-PCR)
- UniSTS:316931

ZK154.7 (e-PCR)
- UniSTS:312487

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Disintegrin and metalloproteinase domain-containing protein 17 homolog

NP_509318.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7794875..7798298 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076917.7 → NP_509318.1 Disintegrin and metalloproteinase domain-containing protein 17 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509318.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94316

Conserved Domains (3) summary

cd04270
Location:187 → 448

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

cd14246
Location:552 → 610

ADAM17_MPD; Membrane-proximal domain of a disintegrin and metalloprotease 17 (ADAM17)

pfam00200
Location:455 → 528

Disintegrin; Disintegrin