paa-1 putative serine/threonine-protein phosphatase PP2A regulatory subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: paa-1
Official Full Name: putative serine/threonine-protein phosphatase PP2A regulatory subunit
Primary source: WormBase:WBGene00003901
Locus tag: CELE_F48E8.5
See related: AllianceGenome:WB:WBGene00003901
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DEAD/H-box RNA helicase binding activity. Involved in embryo development. Located in P granule; microtubule cytoskeleton; and nuclear envelope. Part of protein phosphatase type 2A complex. Is expressed in several structures, including excretory cell; hypodermis; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36 and lung cancer. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha) and PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See paa-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (5450730..5453137)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RSA complex regulates a subset of PP2A functions at the centrosome. Components of the RSA complex, RSA-1 and RSA-2 and are specifically required for microtubule outgrowth from centrosomes and for spindle assembly.
Title: The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F48E8.5 (e-PCR)
- UniSTS:311670

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion, centromeric	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IPI Inferred from Physical Interaction more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative serine/threonine-protein phosphatase PP2A regulatory subunit

NP_498162.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5450730..5453137

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065761.5 → NP_498162.2 putative serine/threonine-protein phosphatase PP2A regulatory subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498162.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09543

UniProtKB/TrEMBL

V5XY55

Conserved Domains (3) summary

pfam02985
Location:523 → 553

HEAT; HEAT repeat

pfam13646
Location:488 → 584

HEAT_2; HEAT repeats

sd00044
Location:248 → 271

HEAT; HEAT repeat [structural motif]