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    E02A10.3 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E02A10.3
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00008453
    Locus tag
    CELE_E02A10.3
    See related
    AllianceGenome:WB:WBGene00008453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in microtubule organizing center. Orthologous to human CETN1 (centrin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See E02A10.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (12579599..12588004)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phosphate carrier protein, mitochondrial Neighboring gene Transthyretin-like family protein Neighboring gene ERAP1_C domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_001256433.1
    • Confirmed by transcript evidence
    NP_001256434.1
    • Confirmed by transcript evidence
    NP_001256435.1
    • Confirmed by transcript evidence
    NP_001343832.1
    • Confirmed by transcript evidence
    NP_001343833.1
    • Confirmed by transcript evidence
    NP_001343834.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12579599..12588004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356744.3 → NP_001343832.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3L3
      Conserved Domains (2) summary
      cd15897
      Location:140 → 167
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:132 → 273
      EFh_PEF; The penta-EF hand (PEF) family

    2. NM_001356745.2 → NP_001343833.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2Z8
      Conserved Domains (2) summary
      cd15897
      Location:41 → 68
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:33 → 174
      EFh_PEF; The penta-EF hand (PEF) family

    3. NM_001269504.3 → NP_001256433.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2E7
      Conserved Domains (2) summary
      PTZ00184
      Location:55 → 196
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:61 → 123
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_001269505.4 → NP_001256434.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2E6
      Conserved Domains (2) summary
      PTZ00184
      Location:51 → 192
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:57 → 119
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. NM_001269506.2 → NP_001256435.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90802
      Conserved Domains (2) summary
      PTZ00184
      Location:51 → 192
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:57 → 119
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. NM_001356746.3 → NP_001343834.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C351
      Conserved Domains (2) summary
      cd15897
      Location:52 → 79
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:44 → 185
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein
    Heading Accession and Version

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