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    C05C9.1 BPI2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C05C9.1
    Official Full Name
    BPI2 domain-containing protein
    Primary source
    WormBase:WBGene00007325
    Locus tag
    CELE_C05C9.1
    See related
    AllianceGenome:WB:WBGene00007325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPIFC (BPI fold containing family C); BPI (bactericidal permeability increasing protein); and LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C05C9.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (11160837..11164006)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ULP_PROTEASE domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA-Leu Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene Alpha-2-macroglobulin domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BPI2 domain-containing protein
    NP_509863.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11160837..11164006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077462.4 → NP_509863.2  BPI2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509863.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17654
      Conserved Domains (2) summary
      smart00328
      Location:21 → 246
      BPI1; BPI/LBP/CETP N-terminal domain
      cl00188
      Location:231 → 468
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
    Nucleotide Protein
    Heading Accession and Version

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