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    mig-6 Papilin [ Caenorhabditis elegans ]

    Gene ID: 179162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-6
    Official Full Name
    Papilin
    Primary source
    WormBase:WBGene00003242
    Locus tag
    CELE_C37C3.6
    See related
    AllianceGenome:WB:WBGene00003242
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including distal tip cell migration; embryo development; and nematode larval development. Located in basement membrane. Is expressed in several structures, including body wall musculature; enteric muscle; nervous system; reproductive system; and somatic gonad precursor. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (7827217..7842390)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Fatty acid-binding protein homolog 4 Neighboring gene EGF-like domain-containing protein Neighboring gene Transthyretin-like protein 33 Neighboring gene Pituitary tumor-transforming gene 1 protein-interacting protein Neighboring gene Ground-like domain-containing protein Neighboring gene Protein MEMO1;Protein memo-1 homolog Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV. Kawano T, et al. Development, 2009 May. PMID 19297413, Free PMC Article
    2. The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. Schindler AJ, et al. Dev Biol, 2011 Sep 15. PMID 21784067, Free PMC Article
    3. 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33. Offenburger SL, et al. PLoS Genet, 2018 Jan. PMID 29346382, Free PMC Article
    4. Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans. Su M, et al. Development, 2000 Feb. PMID 10631179
    5. Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Furuta T, et al. Genesis, 2002 Dec. PMID 12434334

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in distal tip cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Papilin
    NP_001370555.1
    • Confirmed by transcript evidence
    NP_505017.1
    • Confirmed by transcript evidence
    NP_741569.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7827217..7842390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171931.7 → NP_741569.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741569.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76840
      Conserved Domains (4) summary
      smart00209
      Location:79 → 123
      TSP1; Thrombospondin type 1 repeats
      cd00109
      Location:1269 → 1321
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1375 → 1427
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:224 → 336
      ADAM_spacer1; ADAM-TS Spacer 1

    2. NM_072616.7 → NP_505017.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505017.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76840, Q22911, Q8I7I0, Q8MPV5
      Conserved Domains (7) summary
      smart00408
      Location:1999 → 2054
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:79 → 123
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:1998 → 2068
      IG_like; Immunoglobulin like
      cd00109
      Location:1502 → 1555
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1374 → 1426
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:224 → 336
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:2128 → 2160
      PLAC; PLAC (protease and lacunin) domain

    3. NM_001383344.2 → NP_001370555.1  Papilin [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (5) summary
      smart00209
      Location:79 → 123
      TSP1; Thrombospondin type 1 repeats
      cd00109
      Location:1269 → 1321
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:224 → 336
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam00014
      Location:1374 → 1426
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam19030
      Location:405 → 462
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76840.1

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