nlr-1 Neurexin like receptor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nlr-1
Official Full Name: Neurexin like receptor 1
Primary source: WormBase:WBGene00003772
Locus tag: CELE_F20B10.1
See related: AllianceGenome:WB:WBGene00003772
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity and gap junction channel activity. Involved in positive regulation of gap junction assembly and positive regulation of nematode pharyngeal pumping. Located in gap junction. Is expressed in alimentary muscle; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to several human genes including CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nlr-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 16

Sequence:: Chromosome: IV; NC_003282.8 (12170824..12178335, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nlr-1/CNTNAP regulates dopamine circuit structure and foraging behaviors in C. elegans.
Title: nlr-1/CNTNAP regulates dopamine circuit structure and foraging behaviors in C. elegans.
NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.
Title: NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20B10.1 (e-PCR)
- UniSTS:307506

F20B10.2 (e-PCR)
- UniSTS:314087

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables gap junction channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of gap junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neurexin like receptor 1

NP_502312.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12170824..12178335 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069911.6 → NP_502312.2 Neurexin like receptor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502312.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19617

Conserved Domains (4) summary

cd00110
Location:717 → 836

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:448 → 479

EGF; EGF-like domain

pfam02210
Location:154 → 275

Laminin_G_2; Laminin G domain

pfam12661
Location:868 → 885

hEGF; Human growth factor-like EGF