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    col-181 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-181
    Official Full Name
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000754
    Locus tag
    CELE_W03G11.1
    See related
    AllianceGenome:WB:WBGene00000754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human COL5A3 (collagen type V alpha 3 chain) and MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-181 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_003284.9 (12104930..12106102)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Putative alpha-L-fucosidase Neighboring gene tRNA-Lys Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_001041295.1
    • Partially confirmed by transcript evidence
    NP_001041296.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12104930..12106102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047830.5 → NP_001041295.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23150
      Conserved Domains (3) summary
      pfam01391
      Location:258 → 315
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:65 → 117
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
      PRK07764
      Location:164 → 317
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    2. NM_001047831.4 → NP_001041296.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XN04
      Conserved Domains (3) summary
      pfam01391
      Location:205 → 262
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:12 → 64
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
      PRK07764
      Location:111 → 264
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
    Nucleotide Protein
    Heading Accession and Version

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