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    gly-4 Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase [ Caenorhabditis elegans ]

    Gene ID: 180302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gly-4
    Official Full Name
    Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase
    Primary source
    WormBase:WBGene00001629
    Locus tag
    CELE_Y116F11B.12
    See related
    AllianceGenome:WB:WBGene00001629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to several human genes including GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gly-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (19881374..19895350, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene FDX-ACB domain-containing protein;phenylalanine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
    2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
    3. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
    4. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase
    NP_001024216.1
    • Confirmed by transcript evidence
    NP_001256888.1
    • Confirmed by transcript evidence
    NP_001379271.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19881374..19895350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029045.6 → NP_001024216.1  Polypeptide N-acetylgalactosaminyltransferase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61390, Q8I136
      Conserved Domains (3) summary
      cd02510
      Location:154 → 449
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:469 → 582
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:469 → 580
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001392704.1 → NP_001379271.1  Polypeptide N-acetylgalactosaminyltransferase 4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd02510
      Location:154 → 449
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

    3. NM_001269959.4 → NP_001256888.1  polypeptide N-acetylgalactosaminyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6S3M5
      Conserved Domains (1) summary
      cd02510
      Location:154 → 449
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I136.2

    Gene LinkOut

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