mrt-2 Cell cycle checkpoint protein RAD1 homolog mrt-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrt-2
Official Full Name: Cell cycle checkpoint protein RAD1 homolog mrt-2
Primary source: WormBase:WBGene00003417
Locus tag: CELE_Y41C4A.14
See related: AllianceGenome:WB:WBGene00003417
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable damaged DNA binding activity. Involved in DNA metabolic process and intracellular signal transduction. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mrt-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (11746766..11750175)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA damage checkpoint protein mrt-2 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells.
Title: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y41C4A.14 (e-PCR)
- UniSTS:322404

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of checkpoint clamp complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cell cycle checkpoint protein RAD1 homolog mrt-2

NP_499521.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11746766..11750175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067120.5 → NP_499521.1 Cell cycle checkpoint protein RAD1 homolog mrt-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499521.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC44

Conserved Domains (1) summary

pfam02144
Location:11 → 246

Rad1; Repair protein Rad1/Rec1/Rad17