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    nxf-2 Nuclear RNA export factor 2 [ Caenorhabditis elegans ]

    Gene ID: 179938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nxf-2
    Official Full Name
    Nuclear RNA export factor 2
    Primary source
    WormBase:WBGene00003835
    Locus tag
    CELE_C15H11.6
    See related
    AllianceGenome:WB:WBGene00003835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Is expressed in germ cell. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nxf-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (14416067..14417835, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Nuclear RNA export factor 1 Neighboring gene Cytochrome b-c1 complex subunit 10;Essential MCU regulator, mitochondrial Neighboring gene SET domain-containing protein Neighboring gene DeHydrogenases, Short chain Neighboring gene Proteasome subunit alpha type-6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. Tan W, et al. RNA, 2000 Dec. PMID 11142376, Free PMC Article
    2. The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold. Kerkow DE, et al. J Mol Biol, 2012 Jan 27. PMID 22123199, Free PMC Article
    3. REF-ereeing the cytoplasmic fate of mRNA via nuclear export. McKee AE, et al. Dev Cell, 2004 Jun. PMID 15177019
    4. The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Miwa T, et al. Genes Cells, 2022 Oct. PMID 35950937
    5. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
      Title: The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear RNA export factor 2
    NP_506568.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14416067..14417835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074167.8 → NP_506568.2  Nuclear RNA export factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506568.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVS8
      Conserved Domains (2) summary
      sd00035
      Location:55 → 97
      LRR_NTF; leucine-rich repeat [structural motif]
      cd21340
      Location:96 → 159
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein
    Heading Accession and Version

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