fkh-7 Fork-head domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fkh-7
Official Full Name: Fork-head domain-containing protein
Primary source: WormBase:WBGene00001439
Locus tag: CELE_F26D12.1
See related: AllianceGenome:WB:WBGene00001439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; autism spectrum disorder (multiple); autoimmune disease (multiple); communication disorder (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fkh-7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (5584684..5610378)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C39H7.3 (e-PCR)
- UniSTS:321671

F26D12.b (e-PCR)
- UniSTS:323551

F26D12.a (e-PCR)
- UniSTS:322529

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Fork-head domain-containing protein

NP_001023147.1

Partially confirmed by transcript evidence

NP_001023148.1

Partially confirmed by transcript evidence

NP_001293720.1

Confirmed by transcript evidence

NP_001293721.1

Confirmed by transcript evidence

NP_001293723.1

Confirmed by transcript evidence

NP_001293724.1

Confirmed by transcript evidence

NP_001293811.1

Partially confirmed by transcript evidence

NP_001293812.1

Partially confirmed by transcript evidence

NP_001293813.1

Confirmed by transcript evidence

NP_001293814.1

Confirmed by transcript evidence

NP_001293815.1

Confirmed by transcript evidence

NP_001293816.1

Confirmed by transcript evidence

NP_001368377.1

Confirmed by transcript evidence

NP_001368378.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5584684..5610378

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306884.4 → NP_001293813.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLS2

Conserved Domains (2) summary

cd20065
Location:562 → 644

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:326 → 393

FOXP-CC; FOXP coiled-coil domain
NM_001306882.4 → NP_001293811.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLX2

Conserved Domains (2) summary

cd20065
Location:562 → 644

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:326 → 393

FOXP-CC; FOXP coiled-coil domain
NM_001027976.7 → NP_001023147.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q86MF0

Conserved Domains (3) summary

COG5025
Location:515 → 676

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:563 → 636

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:326 → 393

FOXP-CC; FOXP coiled-coil domain
NM_001306885.3 → NP_001293814.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CJE7

Conserved Domains (2) summary

cd20065
Location:562 → 644

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:326 → 393

FOXP-CC; FOXP coiled-coil domain
NM_001027977.5 → NP_001023148.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q86ME9

Conserved Domains (3) summary

COG5025
Location:329 → 490

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:377 → 450

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:140 → 207

FOXP-CC; FOXP coiled-coil domain
NM_001306883.3 → NP_001293812.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLW4

Conserved Domains (2) summary

cd20065
Location:376 → 458

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:140 → 207

FOXP-CC; FOXP coiled-coil domain
NM_001306886.3 → NP_001293815.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CKK8

Conserved Domains (2) summary

cd20065
Location:376 → 458

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:140 → 207

FOXP-CC; FOXP coiled-coil domain
NM_001306887.3 → NP_001293816.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLX8

Conserved Domains (2) summary

cd20065
Location:376 → 458

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

pfam16159
Location:140 → 207

FOXP-CC; FOXP coiled-coil domain
NM_001306791.3 → NP_001293720.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIY1

Conserved Domains (2) summary

COG5025
Location:32 → 284

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd20065
Location:79 → 161

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001380234.1 → NP_001368377.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLH2

Conserved Domains (1) summary

cd20065
Location:79 → 161

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001306794.3 → NP_001293723.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLF5

Conserved Domains (1) summary

cd20065
Location:79 → 161

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001306795.3 → NP_001293724.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLC1

Conserved Domains (1) summary

cd20065
Location:79 → 161

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001306792.3 → NP_001293721.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CK27
NM_001380235.1 → NP_001368378.1 Fork-head domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIY6