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    gba-3 Putative glucosylceramidase 3 [ Caenorhabditis elegans ]

    Gene ID: 178535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gba-3
    Official Full Name
    Putative glucosylceramidase 3
    Primary source
    WormBase:WBGene00008706
    Locus tag
    CELE_F11E6.1
    See related
    AllianceGenome:WB:WBGene00008706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gba-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (17473334..17479397)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-44 Neighboring gene ncRNA Neighboring gene Metalloendopeptidase;Zinc metalloproteinase nas-6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
    2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    3. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article
    4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glucosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative glucosylceramidase 3
    NP_001255965.1
    • Confirmed by transcript evidence
    NP_503118.1
    • Confirmed by transcript evidence
    NP_503119.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17473334..17479397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269036.3 → NP_001255965.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECR8
      Conserved Domains (1) summary
      cl23815
      Location:28 → 521
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    2. NM_070717.4 → NP_503118.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECR8
      Conserved Domains (1) summary
      cl23815
      Location:25 → 518
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    3. NM_070718.4 → NP_503119.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECR8, G5EEA6, G5EFK0, Q8MQ76
      Conserved Domains (1) summary
      cl23815
      Location:25 → 518
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    RNA

    1. NR_132469.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECR8.1

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