cnd-1 Neurogenic differentiation factor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cnd-1
Official Full Name: Neurogenic differentiation factor 1
Primary source: WormBase:WBGene00000561
Locus tag: CELE_C34E10.7
See related: AllianceGenome:WB:WBGene00000561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in axonal fasciculation and negative regulation of gliogenesis. Located in nucleus. Is expressed in several structures, including ABalaa; ABalaaaa; motor neurons; neuroblasts; and somatic nervous system. Used to study developmental and epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72 and glucose metabolism disease (multiple). Orthologous to several human genes including NEUROD1 (neuronal differentiation 1); NEUROD2 (neuronal differentiation 2); and NEUROD4 (neuronal differentiation 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cnd-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (5240591..5244639, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans.
Title: cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34E10.7 (e-PCR)
- UniSTS:317940

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neurogenic differentiation factor 1

NP_001379767.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5240591..5244639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392092.1 → NP_001379767.1 Neurogenic differentiation factor 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P46581

Conserved Domains (2) summary

cd11427
Location:21 → 75

bHLH_TS_NeuroD; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) family

pfam12533
Location:78 → 129

Neuro_bHLH; Neuronal helix-loop-helix transcription factor