set-4 Histone-lysine N-methyltransferase Suv4-20 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: set-4
Official Full Name: Histone-lysine N-methyltransferase Suv4-20
Primary source: WormBase:WBGene00016313
Locus tag: CELE_C32D5.5
See related: AllianceGenome:WB:WBGene00016313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone H4K20me methyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including germ line; hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to human KMT5B (lysine methyltransferase 5B) and KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

These results implicate SET-4 as a sensory rheostat that reinforces developmental fates in response to environmental cues.
Title: A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.

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Function	Evidence Code	Pubs
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_495272.1

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The following sections contain reference sequences that belong to a specific genome build. Explain