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    dpff-1 Zinc finger protein dpff-1 [ Caenorhabditis elegans ]

    Gene ID: 175832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpff-1
    Official Full Name
    Zinc finger protein dpff-1
    Primary source
    WormBase:WBGene00016200
    Locus tag
    CELE_C28H8.9
    See related
    AllianceGenome:WB:WBGene00016200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in apoptotic process; meiotic cell cycle; and response to heat. Located in nucleus. Is expressed widely. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to several human genes including DPF2 (double PHD fingers 2) and DPF3 (double PHD fingers 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpff-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (5903563..5906346, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Paxillin homolog 1 Neighboring gene ER lumen protein-retaining receptor erd-2.2 Neighboring gene putative helicase C28H8.3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline. Villanueva-Chimal E, et al. Genesis, 2017 Nov. PMID 28940692
    2. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
    3. SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Mathies LD, et al. Proc Natl Acad Sci U S A, 2015 Mar 10. PMID 25713357, Free PMC Article
    4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gonads of dpff-1 null mutants showed more germ cells in pachytene, overexpressed the P-MPK-1 signal, produced less progeny and were more sensitive to heat shock.
      Title: DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein dpff-1
    NP_001122678.1
    • Confirmed by transcript evidence
    NP_001359900.1
    • Confirmed by transcript evidence
    NP_498281.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5903563..5906346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065880.8 → NP_498281.2  Zinc finger protein dpff-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498281.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WFG1, H2KZ28, Q09247, Q09477
      Conserved Domains (4) summary
      COG5189
      Location:19 → 236
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15526
      Location:257 → 311
      PHD1_MOZ_d4; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ), its factor (MORF), and d4 gene family proteins
      cd15530
      Location:313 → 358
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      pfam14051
      Location:3 → 77
      Requiem_N; N-terminal domain of DPF2/REQ

    2. NM_001372602.1 → NP_001359900.1  Zinc finger protein dpff-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam14051
      Location:3 → 77
      Requiem_N; N-terminal domain of DPF2/REQ

    3. NM_001129206.5 → NP_001122678.1  Zinc finger protein dpff-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09477
      Conserved Domains (1) summary
      pfam14051
      Location:3 → 77
      Requiem_N; N-terminal domain of DPF2/REQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09477.2

    Gene LinkOut

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    Chemical Information
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