egas-4 EGF-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egas-4
Official Full Name: EGF-like domain-containing protein
Primary source: WormBase:WBGene00018906
Locus tag: CELE_F55G1.13
See related: AllianceGenome:WB:WBGene00018906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egas-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 18

Sequence:: Chromosome: IV; NC_003282.8 (7493743..7497850, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55G1.13 (e-PCR)
- UniSTS:311837

F55G1.14 (e-PCR)
- UniSTS:311838

F55G1.12 (e-PCR)
- UniSTS:322179

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EGF-like domain-containing protein

NP_501207.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7493743..7497850 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068806.4 → NP_501207.2 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501207.2

Status: REVIEWED

UniProtKB/TrEMBL

Q20852

Conserved Domains (3) summary

cd00054
Location:482 → 522

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:101 → 131

EGF; EGF-like domain

pfam00858
Location:610 → 869

ASC; Amiloride-sensitive sodium channel