mib-1 RING-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mib-1
Official Full Name: RING-type domain-containing protein
Primary source: WormBase:WBGene00012933
Locus tag: CELE_Y47D3A.22
See related: AllianceGenome:WB:WBGene00012933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in vulva. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1) and MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mib-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (11286335..11290676, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that knocking down Y47D3A.22/mib-1 improves neuromuscular function in Caenorhabditis elegans deficient in SMN-1.
Title: The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.
ceMIB (Caenorhabditis elegans Mindbomb/Y47D3A.22) plays a role in the regulation of C. elegans Wnt/RYK (lin-18) /TCF signaling.
Title: Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y47D3A.z (e-PCR)
- UniSTS:323684

Y47D3A.y (e-PCR)
- UniSTS:322929

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RING-type domain-containing protein

NP_499452.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11286335..11290676 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067051.7 → NP_499452.2 RING-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499452.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2C5

Conserved Domains (5) summary

cd00204
Location:341 → 459

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:420 → 494

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:382 → 436

Ank_4; Ankyrin repeats (many copies)

pfam13920
Location:717 → 760

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:384 → 413

ANK; ANK repeat [structural motif]