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    scrm-3 Phospholipid scramblase [ Caenorhabditis elegans ]

    Gene ID: 182212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scrm-3
    Official Full Name
    Phospholipid scramblase
    Primary source
    WormBase:WBGene00015437
    Locus tag
    CELE_C04E12.7
    See related
    AllianceGenome:WB:WBGene00015437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; body wall musculature; and nervous system. Orthologous to several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scrm-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (3355848..3357206, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene pseudo Neighboring gene PAW domain-containing protein Neighboring gene PAW domain-containing protein Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Venegas V, et al. Mol Biol Cell, 2007 Aug. PMID 17567952, Free PMC Article
    2. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785
    3. Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system. Von Stetina SE, et al. Genome Biol, 2007. PMID 17612406, Free PMC Article
    4. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Wang X, et al. Nat Cell Biol, 2007 May. PMID 17401362
    5. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid scramblase
    NP_503934.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3355848..3357206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071533.4 → NP_503934.2  Phospholipid scramblase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG07
      Conserved Domains (1) summary
      cl02043
      Location:41 → 249
      LOR; LURP-one-related
    Nucleotide Protein
    Heading Accession and Version

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