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    ulp-2 Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ulp-2
    Official Full Name
    Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein
    Primary source
    WormBase:WBGene00006737
    Locus tag
    CELE_Y38A8.3
    See related
    AllianceGenome:WB:WBGene00006737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable deSUMOylase activity. Involved in adherens junction maintenance; protein desumoylation; and regulation of cell-cell adhesion involved in gastrulation. Located in cytosol and nucleus. Is expressed in hypodermis and neuroblasts. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ulp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (4955450..4959876, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Zygote defective protein 12 Neighboring gene Nudix hydrolase 3 Neighboring gene Proteasome subunit beta type-3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions. Tsur A, et al. Dev Cell, 2015 Oct 12. PMID 26412237
    2. Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Pelisch F, et al. Nat Commun, 2015 Feb 12. PMID 25672768, Free PMC Article
    3. Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Pelisch F, et al. Nat Commun, 2014 Dec 5. PMID 25475837, Free PMC Article
    4. ULP-2 SUMO protease regulates UPR(mt) and mitochondrial homeostasis in Caenorhabditis elegans. Michaeli L, et al. Free Radic Biol Med, 2024 Mar. PMID 38301974, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ULP-2 SUMO protease regulates UPR[mt] and mitochondrial homeostasis in Caenorhabditis elegans.
      Title: ULP-2 SUMO protease regulates UPR(mt) and mitochondrial homeostasis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deSUMOylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell-cell adhesion involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein
    NP_001305240.1
    • Confirmed by transcript evidence
    NP_001305241.1
    • Confirmed by transcript evidence
    NP_494914.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4955450..4959876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318311.3 → NP_001305240.1  Ubiquitin-like protease family profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XR45
      Conserved Domains (1) summary
      pfam02902
      Location:371 → 609
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_062513.6 → NP_494914.1  Ubiquitin-like protease 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23238
      Conserved Domains (1) summary
      pfam02902
      Location:553 → 771
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. NM_001318312.3 → NP_001305241.1  Ubiquitin-like protease family profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XRS7
      Conserved Domains (1) summary
      pfam02902
      Location:1 → 232
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23238.2

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