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    aex-1 C2 domain-containing protein aex-1 [ Caenorhabditis elegans ]

    Gene ID: 172519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aex-1
    Official Full Name
    C2 domain-containing protein aex-1
    Primary source
    WormBase:WBGene00000084
    Locus tag
    CELE_D2030.10
    See related
    AllianceGenome:WB:WBGene00000084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including egg-laying behavior; positive regulation of intestinal lipid absorption; and positive regulation of transport. Predicted to be located in exocytic vesicle. Predicted to be active in secretory vesicle. Is expressed in amphid neurons; body wall musculature; and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aex-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (7602307..7608245)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PC-esterase domain-containing protein 1B Neighboring gene DDB1- and CUL4-associated factor 11 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Low-density lipoprotein receptor-related protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1. Yamashita M, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19028454, Free PMC Article
    2. Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program. Sheng M, et al. PLoS One, 2015. PMID 25849533, Free PMC Article
    3. Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1. Doi M, et al. Neuron, 2002 Jan 17. PMID 11804572
    4. Caenorhabditis elegans twist plays an essential role in non-striated muscle development. Corsi AK, et al. Development, 2000 May. PMID 10769229
    5. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Mahoney TR, et al. Proc Natl Acad Sci U S A, 2008 Oct 21. PMID 18852466, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that a novel molecular interaction between the AEX-1 and syntaxin may regulate vesicle exocytosis for retrograde signal release.
      Title: The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport involved in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of acetylcholine secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intestinal lipid absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in exocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in secretory vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein aex-1
    NP_001021074.1
    • Partially confirmed by transcript evidence
    NP_740891.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7602307..7608245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170901.4 → NP_740891.1  C2 domain-containing protein aex-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740891.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEU3
      Conserved Domains (1) summary
      cl14603
      Location:854 → 948
      C2; C2 domain

    2. NM_001025903.4 → NP_001021074.1  C2 domain-containing protein aex-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECE1
      Conserved Domains (1) summary
      cl14603
      Location:854 → 916
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEU3.1

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