dyf-11 TRAF3-interacting protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dyf-11
Official Full Name: TRAF3-interacting protein 1
Primary source: WormBase:WBGene00001127
Locus tag: CELE_C02H7.1
See related: AllianceGenome:WB:WBGene00001127
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable microtubule binding activity. Involved in several processes, including cilium organization; dauer entry; and hyperosmotic response. Located in axoneme and ciliary basal body. Part of intraciliary transport particle B. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dyf-11 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (763752..766739)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DYF-11 is likely associated with IFT complex B. Domain analysis using DYF-11 deletion constructs revealed that the coiled-coil region is required for proper localization and ciliogenesis.
Title: Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1/MIP-T3, is required for sensory cilia formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C02H7.1 (e-PCR)
- UniSTS:308436

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TRAF3-interacting protein 1

NP_508149.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

763752..766739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075748.5 → NP_508149.1 TRAF3-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508149.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17595

Conserved Domains (1) summary

pfam10243
Location:46 → 535

MIP-T3; Microtubule-binding protein MIP-T3