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    rpn-5 PCI domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpn-5
    Official Full Name
    PCI domain-containing protein
    Primary source
    WormBase:WBGene00004461
    Locus tag
    CELE_F10G7.8
    See related
    AllianceGenome:WB:WBGene00004461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be part of proteasome regulatory particle, lid subcomplex. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; rectum; and reproductive system. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpn-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (4696421..4698294, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MFS domain-containing protein Neighboring gene Sister chromatid cohesion protein 1 Neighboring gene putative histone chaperone asf-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Lehrbach NJ, et al. Elife, 2019 Apr 11. PMID 30973820, Free PMC Article
    2. Muscle-derived exophers promote reproductive fitness. Turek M, et al. EMBO Rep, 2021 Aug 4. PMID 34288362, Free PMC Article
    3. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
    4. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Ghazi A, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17392428, Free PMC Article
    5. Proteasome activation delays aging in vitro and in vivo. Chondrogianni N, et al. Free Radic Biol Med, 2014 Jun. PMID 24681338

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PCI domain-containing protein
    NP_494835.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4696421..4698294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062434.6 → NP_494835.1  PCI domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19324
      Conserved Domains (1) summary
      COG5071
      Location:38 → 480
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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