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    magu-3 Guanylate kinase-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    magu-3
    Official Full Name
    Guanylate kinase-like domain-containing protein
    Primary source
    WormBase:WBGene00016841
    Locus tag
    CELE_C50F2.8
    See related
    AllianceGenome:WB:WBGene00016841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinase activity. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in intestine; pharynx; and tail. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See magu-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (3901421..3905208, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene peptidylprolyl isomerase Neighboring gene Sialomucin core protein 24 Neighboring gene ncRNA Neighboring gene Proteasome subunit beta type-2 Neighboring gene Ribosome-recycling factor, mitochondrial Neighboring gene TPA-induced transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Guanylate kinase-like domain-containing protein
    NP_491260.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3901421..3905208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058859.5 → NP_491260.2  Guanylate kinase-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491260.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91182
      Conserved Domains (3) summary
      pfam00625
      Location:282 → 464
      Guanylate_kin; Guanylate kinase
      cl00117
      Location:147 → 204
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl17036
      Location:218 → 268
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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