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    gpla-1 Bursicon [ Caenorhabditis elegans ]

    Gene ID: 186548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpla-1
    Official Full Name
    Bursicon
    Primary source
    WormBase:WBGene00001466
    Locus tag
    CELE_F58H1.4
    See related
    AllianceGenome:WB:WBGene00001466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in extracellular space. Is expressed in neurons. Orthologous to human GPHA2 (glycoprotein hormone subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpla-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (11936505..11937810, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alpha-mannosidase Neighboring gene Secreted protein Neighboring gene Enolase-phosphatase E1 Neighboring gene Uncharacterized protein Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi M, et al. Proc Natl Acad Sci U S A, 1998 Sep 29. PMID 9751741, Free PMC Article
    2. FLR-2, the glycoprotein hormone alpha subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans. Oishi A, et al. Genes Cells, 2009 Oct. PMID 19735483
    3. Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans. Torzone SK, et al. PLoS Biol, 2023 Sep. PMID 37773960, Free PMC Article
    4. GPCR signaling regulates severe stress-induced organismic death in Caenorhabditis elegans. Wang C, et al. Aging Cell, 2023 Jan. PMID 36415159, Free PMC Article
    5. Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans. Kenis S, et al. Front Endocrinol (Lausanne), 2023. PMID 37409228, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bursicon
    NP_505998.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11936505..11937810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073597.3 → NP_505998.3  Bursicon [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8KHX6, Q21013
    Nucleotide Protein
    Heading Accession and Version

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