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    efn-2 Ephrin RBD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    efn-2
    Official Full Name
    Ephrin RBD domain-containing protein
    Primary source
    WormBase:WBGene00001163
    Locus tag
    CELE_C43F9.8
    See related
    AllianceGenome:WB:WBGene00001163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ephrin receptor binding activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory gland cell; head neurons; motor neurons; pharyngeal muscle cell; and retrovesicular ganglion neurons. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; craniofrontonasal syndrome; dysostosis; and esophagus squamous cell carcinoma. Orthologous to several human genes including EFNB1 (ephrin B1) and EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See efn-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (10576350..10578288)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Acyl_transf_3 domain-containing protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor. Wang X, et al. Mol Cell, 1999 Dec. PMID 10635316
    2. Regulation of axonal midline guidance by prolyl 4-hydroxylation in Caenorhabditis elegans. Torpe N, et al. J Neurosci, 2014 Dec 3. PMID 25471573, Free PMC Article
    3. Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans. Li X, et al. Cell Death Differ, 2012 Jun. PMID 22240896, Free PMC Article
    4. The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Harrington RJ, et al. Development, 2002 May. PMID 11959824
    5. A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function. Boulin T, et al. Curr Biol, 2006 Oct 10. PMID 17027485

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ephrin RBD domain-containing protein
    NP_501955.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10576350..10578288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069554.8 → NP_501955.2  Ephrin RBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501955.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3M2
      Conserved Domains (1) summary
      cd02675
      Location:21 → 154
      Ephrin_ectodomain; Ectodomain of Ephrins
    Nucleotide Protein
    Heading Accession and Version

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