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    str-3 Seven TM Receptor [ Caenorhabditis elegans ]

    Gene ID: 187459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    str-3
    Official Full Name
    Seven TM Receptor
    Primary source
    WormBase:WBGene00006071
    Locus tag
    CELE_M7.13
    See related
    AllianceGenome:WB:WBGene00006071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and olfactory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ASIL and ASIR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See str-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (11098448..11100371, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans. Park J, et al. Mol Cells, 2019 Jan 31. PMID 30453729, Free PMC Article
    2. Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans. Peckol EL, et al. Proc Natl Acad Sci U S A, 2001 Sep 25. PMID 11572964, Free PMC Article
    3. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Dwyer ND, et al. Cell, 1998 May 1. PMID 9590179
    4. Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Kim K, et al. Science, 2009 Nov 13. PMID 19797623, Free PMC Article
    5. CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression. Park J, et al. PLoS Genet, 2021 Jul. PMID 34260587, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pheromone-mediated str-3 repression is mediated by FLP-18 neuropeptide signaling via the NPR-1 neuropeptide receptor.
      Title: Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled olfactory receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Seven TM Receptor
    NP_502071.2
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11098448..11100371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069670.2 → NP_502071.2  Seven TM Receptor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502071.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17973
      Conserved Domains (1) summary
      pfam10326
      Location:13 → 319
      7TM_GPCR_Str; Serpentine type 7TM GPCR chemoreceptor Str
    Nucleotide Protein
    Heading Accession and Version

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