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    epg-2 Ectopic P granules protein 2 [ Caenorhabditis elegans ]

    Gene ID: 171787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-2
    Official Full Name
    Ectopic P granules protein 2
    Primary source
    WormBase:WBGene00021468
    Locus tag
    CELE_Y39G10AR.10
    See related
    AllianceGenome:WB:WBGene00021468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in macroautophagy and negative regulation of autophagosome assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (2300086..2302813)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 7 Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene TPX2 domain-containing protein Neighboring gene Inner centromere protein ARK-binding domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA recruitment switches the fate of protein condensates from autophagic degradation to accumulation. Zheng H, et al. J Cell Biol, 2023 Jun 5. PMID 37014300, Free PMC Article
    2. Four metazoan autophagy genes regulate cargo recognition, autophagosome formation and autolysosomal degradation. Tian Y, et al. Autophagy, 2010 Oct. PMID 20814246
    3. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. Zhang G, et al. Autophagy, 2017 Sep 2. PMID 28806108, Free PMC Article
    4. Arginine methylation modulates autophagic degradation of PGL granules in C. elegans. Li S, et al. Mol Cell, 2013 Nov 7. PMID 24140420
    5. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectopic P granules protein 2
    NP_490955.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2300086..2302813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058554.7 → NP_490955.1  Ectopic P granules protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XR4
      Conserved Domains (2) summary
      COG1196
      Location:264 → 606
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:14 → 413
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XR4.1

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