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    ubc-3 UBC core domain-containing protein;UBIQUITIN_CONJUGAT_2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubc-3
    Official Full Name
    UBC core domain-containing protein;UBIQUITIN_CONJUGAT_2 domain-containing protein
    Primary source
    WormBase:WBGene00006702
    Locus tag
    CELE_Y71G12B.15
    See related
    AllianceGenome:WB:WBGene00006702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in body wall musculature; nervous system; pharynx; and seam cell. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme) and UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ubc-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (1698349..1701128)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine phosphatase;Tyrosine-protein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene Sm domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans. Poush JA, et al. Sci Rep, 2018 Dec 10. PMID 30531803, Free PMC Article
    2. Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development. Dove KK, et al. Proc Natl Acad Sci U S A, 2017 Aug 8. PMID 28739890, Free PMC Article
    3. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBC core domain-containing protein;UBIQUITIN_CONJUGAT_2 domain-containing protein
    NP_001293441.1
    • Confirmed by transcript evidence
    NP_490882.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1698349..1701128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058481.9 → NP_490882.3  UBC core domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490882.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XN7
      Conserved Domains (1) summary
      cd00195
      Location:13 → 168
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001306512.3 → NP_001293441.1  UBIQUITIN_CONJUGAT_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY98
    Nucleotide Protein
    Heading Accession and Version

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