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    rnh-2 Ribonuclease H2 subunit A [ Caenorhabditis elegans ]

    Gene ID: 266861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnh-2
    Official Full Name
    Ribonuclease H2 subunit A
    Primary source
    WormBase:WBGene00004383
    Locus tag
    CELE_T13H5.7
    See related
    AllianceGenome:WB:WBGene00004383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnh-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8517150..8518407)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein Neighboring gene DB domain-containing protein Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene Lipid scramblase CLPTM1L Neighboring gene GH18 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Arudchandran A, et al. Mol Biol Evol, 2002 Nov. PMID 12411600
    2. R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline. Hicks T, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35871299, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ribonuclease H2 subunit A
    NP_495796.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8517150..8518407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063395.5 → NP_495796.1  Ribonuclease H2 subunit A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495796.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U6P6
      Conserved Domains (1) summary
      cd07181
      Location:24 → 248
      RNase_HII_eukaryota_like; Eukaryotic RNase HII
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U6P6.1

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