hgrs-1 Hepatocyte growth factor-regulated tyrosine kinase substrate [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hgrs-1
Official Full Name: Hepatocyte growth factor-regulated tyrosine kinase substrate
Primary source: WormBase:WBGene00004101
Locus tag: CELE_C07G1.5
See related: AllianceGenome:WB:WBGene00004101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Is expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hgrs-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (8201429..8205065, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex.
Title: STAM and Hrs down-regulate ciliary TRP receptors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07G1.5 (e-PCR)
- UniSTS:308509

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT-0 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Hepatocyte growth factor-regulated tyrosine kinase substrate

NP_501375.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8201429..8205065 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068974.9 → NP_501375.2 Hepatocyte growth factor-regulated tyrosine kinase substrate [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501375.2

Status: REVIEWED

UniProtKB/TrEMBL

Q17796

Conserved Domains (3) summary

cd03569
Location:1 → 142

VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...

cd15720
Location:156 → 215

FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins

pfam12210
Location:403 → 497

Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate