alp-1 LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: alp-1
Official Full Name: LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp
Primary source: WormBase:WBGene00001132
Locus tag: CELE_T11B7.4
See related: AllianceGenome:WB:WBGene00001132
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Involved in determination of adult lifespan and nematode pharyngeal pumping. Located in several cellular components, including actin filament bundle; basal part of cell; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; nervous system; and pharynx. Used to study cardiomyopathy and myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to several human genes including PDLIM5 (PDZ and LIM domain 5). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See alp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 18

Sequence:: Chromosome: IV; NC_003282.8 (8852494..8862246)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALP-1 serves as a platform to activate MLC-4 phosphorylation mediated by the RHO-1-LET-502 signaling pathway.
Title: The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway.
new roles for the ALP/Enigma protein family that may lead to the understanding of their involvement in cardiomyopathy
Title: Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.
ALP-1 and alpha-actinin function together to stabilize actin filaments and promote muscle structural integrity.
Title: The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T11B7.5 (e-PCR)
- UniSTS:318485

T11B7.4 (e-PCR)
- UniSTS:311630

STS4-159 (e-PCR)
- UniSTS:242148

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables muscle alpha-actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp

NP_001023370.1

Confirmed by transcript evidence

NP_001023371.1

Confirmed by transcript evidence

NP_001040987.1

Confirmed by transcript evidence

NP_001367079.1

Confirmed by transcript evidence

NP_501534.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8852494..8862246

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047522.4 → NP_001040987.1 PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040987.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFG1

Conserved Domains (7) summary

smart00735
Location:137 → 162

ZM; ZASP-like motif

cd09360
Location:220 → 271

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:511 → 564

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:631 → 684

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:5 → 80

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:137 → 197

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:572 → 623

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_069133.5 → NP_501534.2 PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501534.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EEL1

Conserved Domains (7) summary

smart00735
Location:137 → 162

ZM; ZASP-like motif

cd09360
Location:220 → 271

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:472 → 525

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:592 → 645

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:5 → 80

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:137 → 197

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:533 → 584

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001028200.6 → NP_001023371.1 PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023371.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFL5

Conserved Domains (7) summary

smart00735
Location:137 → 162

ZM; ZASP-like motif

cd09360
Location:220 → 271

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1251 → 1304

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1371 → 1424

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:5 → 80

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:137 → 197

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:1312 → 1363

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001380387.2 → NP_001367079.1 PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EC72

Conserved Domains (4) summary

smart00735
Location:137 → 162

ZM; ZASP-like motif

cd09360
Location:220 → 271

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd00992
Location:5 → 80

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:137 → 199

DUF4749; Domain of unknown function (DUF4749)
NM_001028199.5 → NP_001023370.1 LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023370.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEF6

Conserved Domains (6) summary

smart00735
Location:66 → 91

ZM; ZASP-like motif

cd09360
Location:149 → 200

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:598 → 651

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:718 → 771

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

pfam15936
Location:66 → 126

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:659 → 710

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers