slo-2 Ion_trans_2 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: slo-2
Official Full Name: Ion_trans_2 domain-containing protein
Primary source: WormBase:WBGene00004831
Locus tag: CELE_F08B12.3
See related: AllianceGenome:WB:WBGene00004831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Is expressed in body wall musculature; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See slo-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 27

Sequence:: Chromosome: X; NC_003284.9 (11394605..11405931, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutations of HRPU-2, a worm homolog of mammalian hnRNP U, result in dysfunction of a Slo2 potassium channel, which is critical to neuronal function
Title: HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel in Caenorhabditis elegans.
Decreased Slo-2 expression reduced behavioral impairment during ethanol withdrawal.
Title: Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in Caenorhabditis elegans.
SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
SLO-2 potassium channel is an important regulator of neurotransmitter release.
Title: SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans.
The C. elegans SLO-2 channels possess unique biophysical and functional properties.
Title: SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.
in vivo SLO-2 channels were active only when intracellular Ca2+ and Cl- were raised above normal physiological conditions
Title: Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08B12.3 (e-PCR)
- UniSTS:321340

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables intracellular sodium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ion_trans_2 domain-containing protein

NP_001024527.1

Confirmed by transcript evidence

NP_001024528.1

Confirmed by transcript evidence

NP_001024529.1

Confirmed by transcript evidence

NP_001129924.1

Confirmed by transcript evidence

NP_001257144.1

Confirmed by transcript evidence

NP_001257145.1

Partially confirmed by transcript evidence

NP_001257146.1

Partially confirmed by transcript evidence

NP_001257147.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11394605..11405931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029357.5 → NP_001024528.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024528.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDJ1

Conserved Domains (3) summary

pfam00520
Location:117 → 289

Ion_trans; Ion transport protein

pfam03493
Location:451 → 546

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:219 → 291

Ion_trans_2; Ion channel
NM_001029356.4 → NP_001024527.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024527.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ECD1

Conserved Domains (3) summary

pfam00520
Location:117 → 289

Ion_trans; Ion transport protein

pfam03493
Location:451 → 546

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:219 → 291

Ion_trans_2; Ion channel
NM_001136452.4 → NP_001129924.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129924.1

Status: REVIEWED

UniProtKB/TrEMBL

B2MZB8

Conserved Domains (3) summary

pfam00520
Location:114 → 286

Ion_trans; Ion transport protein

pfam03493
Location:448 → 543

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:216 → 288

Ion_trans_2; Ion channel
NM_001029358.5 → NP_001024529.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024529.1

Status: REVIEWED

UniProtKB/TrEMBL

Q565B7

Conserved Domains (3) summary

pfam00520
Location:96 → 268

Ion_trans; Ion transport protein

pfam03493
Location:430 → 525

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:198 → 270

Ion_trans_2; Ion channel
NM_001270215.3 → NP_001257144.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257144.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2R6

Conserved Domains (3) summary

pfam00520
Location:150 → 322

Ion_trans; Ion transport protein

pfam03493
Location:484 → 579

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:252 → 324

Ion_trans_2; Ion channel
NM_001270216.3 → NP_001257145.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257145.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2R3

Conserved Domains (3) summary

pfam00520
Location:135 → 307

Ion_trans; Ion transport protein

pfam03493
Location:469 → 564

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:237 → 309

Ion_trans_2; Ion channel
NM_001270217.4 → NP_001257146.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257146.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2R4

Conserved Domains (3) summary

pfam00520
Location:153 → 320

Ion_trans; Ion transport protein

pfam03493
Location:487 → 582

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:255 → 327

Ion_trans_2; Ion channel
NM_001270218.3 → NP_001257147.1 Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257147.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2R7

Conserved Domains (3) summary

pfam00520
Location:140 → 312

Ion_trans; Ion transport protein

pfam03493
Location:474 → 569

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:242 → 314

Ion_trans_2; Ion channel