mlc-2 Myosin regulatory light chain 2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: mlc-2
Official Full Name: Myosin regulatory light chain 2
Primary source: WormBase:WBGene00003370
Locus tag: CELE_C36E6.5
See related: AllianceGenome:WB:WBGene00003370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of nematode pharyngeal pumping. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

NP_510828.1

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The following sections contain reference sequences that belong to a specific genome build. Explain