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    cpr-3 Cathepsin B-like cysteine proteinase 3 [ Caenorhabditis elegans ]

    Gene ID: 180033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpr-3
    Official Full Name
    Cathepsin B-like cysteine proteinase 3
    Primary source
    WormBase:WBGene00000783
    Locus tag
    CELE_T10H4.12
    See related
    AllianceGenome:WB:WBGene00000783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Involved in innate immune response. Predicted to be active in extracellular space and lysosome. Is expressed in intestine; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpr-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (15296834..15298700, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Seven TM Receptor Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. Larminie CG, et al. DNA Cell Biol, 1996 Jan. PMID 8561899
    2. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. Liontis T, et al. BBA Adv, 2023. PMID 37082252, Free PMC Article
    3. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Luke CJ, et al. Cell, 2007 Sep 21. PMID 17889653, Free PMC Article
    4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cathepsin B-like cysteine proteinase 3
    NP_506790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15296834..15298700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074389.5 → NP_506790.1  Cathepsin B-like cysteine proteinase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43507, Q9TW93
      Conserved Domains (1) summary
      cd02620
      Location:93 → 334
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43507.1

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