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    Nudt12 nudix hydrolase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367323, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nudt12provided by RGD
    Official Full Name
    nudix hydrolase 12provided by RGD
    Primary source
    RGD:1310902
    See related
    EnsemblRapid:ENSRNOG00000022576 AllianceGenome:RGD:1310902
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity; phosphodiesterase decapping endonuclease activity; and pyrophosphatase activity. Predicted to be involved in RNA decapping; nicotinamide nucleotide metabolic process; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 182.6), Liver (RPKM 90.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt12 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (106188930..106202340, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (98741627..98755039, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (105680603..105693374, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480423 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene uncharacterized LOC108351976 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
    2. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Grudzien-Nogalska E, et al. Nat Chem Biol, 2019 Jun. PMID 31101919, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA NAD-cap (NMN-forming) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphodiesterase decapping endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NAD catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA methylguanosine-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NAD-capped RNA hydrolase NUDT12
    Names
    nudix (nucleoside diphosphate linked moiety X)-type motif 12
    nudix-type motif 12
    peroxisomal NADH pyrophosphatase NUDT12
    NP_001102480.1
    XP_006245650.1
    XP_038939942.1
    XP_038939943.1
    XP_063123616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109010.1 → NP_001102480.1  NAD-capped RNA hydrolase NUDT12

      See identical proteins and their annotated locations for NP_001102480.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473997
      UniProtKB/TrEMBL
      A6JR91, D4A2H8
      Related
      ENSRNOP00000061974.2, ENSRNOT00000066968.4
      Conserved Domains (7) summary
      COG2816
      Location:126 → 457
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:147 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 311
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:14 → 43
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      106188930..106202340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084015.2 → XP_038939943.1  NAD-capped RNA hydrolase NUDT12 isoform X3

      Conserved Domains (1) summary
      COG2816
      Location:110 → 312
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    2. XM_006245588.5 → XP_006245650.1  NAD-capped RNA hydrolase NUDT12 isoform X1

      See identical proteins and their annotated locations for XP_006245650.1

      UniProtKB/TrEMBL
      A6JR91, D4A2H8
      Conserved Domains (7) summary
      COG2816
      Location:126 → 457
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:147 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 311
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:14 → 43
      ANK; ANK repeat [structural motif]

    3. XM_039084014.2 → XP_038939942.1  NAD-capped RNA hydrolase NUDT12 isoform X3

      Conserved Domains (1) summary
      COG2816
      Location:110 → 312
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    4. XM_063267546.1 → XP_063123616.1  NAD-capped RNA hydrolase NUDT12 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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