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    Ptges3l1 prostaglandin E synthase 3-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367808, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ptges3l1provided by RGD
    Official Full Name
    prostaglandin E synthase 3-like 1provided by RGD
    Primary source
    RGD:1359350
    See related
    EnsemblRapid:ENSRNOG00000060486 AllianceGenome:RGD:1359350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Hsp90 protein binding activity; prostaglandin-E synthase activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including prostaglandin biosynthetic process; protein-containing complex assembly; and telomere maintenance via telomerase. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 167.4), Thymus (RPKM 161.2) and 9 other tissues See more
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    Genomic context

    See Ptges3l1 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (46092665..46101937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (42215200..42224472, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (45410545..45419817, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene odorant-binding protein-like Neighboring gene anomalous homeobox Neighboring gene steroid sulfatase Neighboring gene patatin like phospholipase domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomerase holoenzyme complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prostaglandin E synthase 3
    NP_001014294.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014272.1NP_001014294.1  prostaglandin E synthase 3

      See identical proteins and their annotated locations for NP_001014294.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087125
      UniProtKB/TrEMBL
      Q5PQL9
      Related
      ENSRNOP00000111637.1, ENSRNOT00000145489.1
      Conserved Domains (1) summary
      cl00175
      Location:398
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      46092665..46101937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)