Npy6r neuropeptide Y receptor Y6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npy6rprovided by MGI
Official Full Name: neuropeptide Y receptor Y6provided by MGI
Primary source: MGI:MGI:1098590
See related: Ensembl:ENSMUSG00000038071 AllianceGenome:MGI:1098590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables peptide YY receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be active in neuron projection and plasma membrane. Is expressed in embryo. Orthologous to human NPY6R (neuropeptide Y receptor Y6 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward bladder adult (RPKM 23.1) See more
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Genomic context

Location:: 18 B3; 18 23.74 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (44403175..44410767)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (44270108..44277700)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

y6R signalling is required for maintenance of bone mass, with loss of y6R uncoupling bone remodelling and resulting in a negative bone balance.
Title: The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay.
PP-initiated signaling through Npy6r in vasoactive intestinal peptide neurons regulates the growth hormone axis and body composition.
Title: Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

Npy6r (e-PCR), detects polymorphism
- UniSTS:144065

NoName (e-PCR)
- UniSTS:489154

PMC60063P2 (e-PCR)
- UniSTS:273385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 6

Names: NPY6-R; PP2; pancreatic polypeptide receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010935.4 → NP_035065.1 neuropeptide Y receptor type 6

See identical proteins and their annotated locations for NP_035065.1

Status: VALIDATED

Source sequence(s)

AC132130

Consensus CDS

CCDS29227.1

UniProtKB/Swiss-Prot

Q3ZAW3, Q61212

Related

ENSMUSP00000040797.4, ENSMUST00000042747.4

Conserved Domains (2) summary

pfam00001
Location:52 → 318

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:46 → 95

7tm_4; Olfactory receptor