U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Peli2 pellino E3 ubiquitin protein ligase family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305835, updated on 27-Nov-2024

    Summary

    Official Symbol
    Peli2provided by RGD
    Official Full Name
    pellino E3 ubiquitin protein ligase family member 2provided by RGD
    Primary source
    RGD:1565884
    See related
    EnsemblRapid:ENSRNOG00000012363 AllianceGenome:RGD:1565884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565884
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in cytosol and membrane. Orthologous to human PELI2 (pellino E3 ubiquitin protein ligase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 128.2), Lung (RPKM 44.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Peli2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (23872984..24017448)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (21393262..21537737)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (24942218..25086350)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482092 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134482091 Neighboring gene uncharacterized LOC102554413 Neighboring gene uncharacterized LOC120097124

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Toll signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase pellino homolog 2
    Names
    pellino 2
    pellino homolog 2
    protein pellino homolog 2
    NP_001100729.1
    XP_017455153.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107259.1NP_001100729.1  E3 ubiquitin-protein ligase pellino homolog 2

      See identical proteins and their annotated locations for NP_001100729.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474040
      UniProtKB/TrEMBL
      A0A8I5YCN0, A6KE60, D3ZSK3
      Related
      ENSRNOP00000016629.5, ENSRNOT00000016629.7
      Conserved Domains (1) summary
      pfam04710
      Location:12419
      Pellino

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      23872984..24017448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599664.3XP_017455153.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6KE62
      Related
      ENSRNOP00000078130.2, ENSRNOT00000097636.2