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    Inha inhibin subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Inhaprovided by RGD
    Official Full Name
    inhibin subunit alphaprovided by RGD
    Primary source
    RGD:2912
    See related
    EnsemblRapid:ENSRNOG00000020097 AllianceGenome:RGD:2912
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Located in several cellular components, including neuronal cell body; photoreceptor inner segment; and photoreceptor outer segment. Part of inhibin A complex and inhibin B complex. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 277.3), Heart (RPKM 175.3) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Inha in Genome Data Viewer
    Location:
    9q33
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84443109..84446010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76994465..76997366)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82700482..82703383)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor Neighboring gene transmembrane protein 198 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene solute carrier family 4 member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93593

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inhibin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemoglobin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of follicle-stimulating hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of inhibin A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of inhibin A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inhibin B complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of inhibin-betaglycan-ActRII complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibin alpha chain
    Names
    inhibin alpha subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012590.2NP_036722.1  inhibin alpha chain precursor

      See identical proteins and their annotated locations for NP_036722.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083564
      UniProtKB/Swiss-Prot
      P17490
      UniProtKB/TrEMBL
      A6JW45
      Related
      ENSRNOP00000027227.2, ENSRNOT00000027227.6
      Conserved Domains (1) summary
      smart00204
      Location:263366
      TGFB; Transforming growth factor-beta (TGF-beta) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84443109..84446010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)