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    Chek1 checkpoint kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140583, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chek1provided by RGD
    Official Full Name
    checkpoint kinase 1provided by RGD
    Primary source
    RGD:620545
    See related
    EnsemblRapid:ENSRNOG00000071217 AllianceGenome:RGD:620545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase activity. Involved in several processes, including cellular response to caffeine; negative regulation of DNA biosynthetic process; and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 60.4), Spleen (RPKM 33.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Chek1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44609417..44629867, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36420565..36443477, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39181162..39201588, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene secreted seminal-vesicle Ly-6 protein 1-like 1 Neighboring gene acrosomal vesicle protein 1 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene EI24, autophagy associated transmembrane protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3T11 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3T11 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process involved in development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to caffeine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2/M transition checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression, epigenetic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic centrosome separation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Chk1
    Names
    CHK1 checkpoint homolog
    checkpoint kinase 1 homolog
    NP_536325.1
    XP_008764264.1
    XP_008764265.1
    XP_038936653.1
    XP_038936654.1
    XP_063120868.1
    XP_063120869.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080400.2NP_536325.1  serine/threonine-protein kinase Chk1

      See identical proteins and their annotated locations for NP_536325.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q91ZN6, Q91ZN7
      UniProtKB/TrEMBL
      A0A8L2UQ45, A6KRN1
      Related
      ENSRNOP00000011226.4, ENSRNOT00000011226.7
      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      44609417..44629867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766042.4XP_008764264.1  serine/threonine-protein kinase Chk1 isoform X1

      See identical proteins and their annotated locations for XP_008764264.1

      UniProtKB/Swiss-Prot
      Q91ZN6, Q91ZN7
      UniProtKB/TrEMBL
      A0A8L2UQ45, A6KRN1
      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
    2. XM_008766043.3XP_008764265.1  serine/threonine-protein kinase Chk1 isoform X1

      See identical proteins and their annotated locations for XP_008764265.1

      UniProtKB/Swiss-Prot
      Q91ZN6, Q91ZN7
      UniProtKB/TrEMBL
      A0A8L2UQ45, A6KRN1
      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
    3. XM_039080725.2XP_038936653.1  serine/threonine-protein kinase Chk1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:199
      PKc_like; Protein Kinases, catalytic domain
    4. XM_063264798.1XP_063120868.1  serine/threonine-protein kinase Chk1 isoform X2

    5. XM_063264799.1XP_063120869.1  serine/threonine-protein kinase Chk1 isoform X4

    6. XM_039080726.2XP_038936654.1  serine/threonine-protein kinase Chk1 isoform X3

      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1