Ano2 anoctamin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ano2provided by RGD
Official Full Name: anoctamin 2provided by RGD
Primary source: RGD:1591606
See related: EnsemblRapid:ENSRNOG00000023561 AllianceGenome:RGD:1591606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to act upstream of or within chloride transport and establishment of localization in cell. Predicted to be located in neuron projection; non-motile cilium; and nucleoplasm. Predicted to be active in glutamatergic synapse and presynaptic membrane. Orthologous to human ANO2 (anoctamin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 7.8), Lung (RPKM 7.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (160200471..160541830)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (158514200..158855639)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (158222650..158577595)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands.
Title: TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands.
Rod photoreceptor terminals possess the molecular machinery for chloride accumulation and for the generation of calcium-dependent chloride currents conducted through anoctamin 2 channels.
Title: Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina.
the main functional features of ANO 1 and ANO 2 chloride channels in the nose and suggest their significance for nasal physiology.
Title: Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Got132 (e-PCR)
- UniSTS:114607

BE120014 (e-PCR)
- UniSTS:247224

AU046876 (e-PCR)
- UniSTS:111053

AU049195 (e-PCR)
- UniSTS:145643

RH139336 (e-PCR)
- UniSTS:221422

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly calcium-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly calcium-gated chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
NOT enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anoctamin 2; anoctamin-2

Names: anoctamin 2, calcium activated chloride channel; anoctamin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431940.1 → NP_001418869.1 anoctamin 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GJA0, F1M3G8
NM_001431941.1 → NP_001418870.1 anoctamin 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GJA0
NM_001431942.1 → NP_001418871.1 anoctamin 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JU76

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

160200471..160541830

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593038.3 → XP_017448527.2 anoctamin-2 isoform X4

UniProtKB/TrEMBL

A0A0G2JXB5

Related

ENSRNOP00000070208.2, ENSRNOT00000084240.3

Conserved Domains (2) summary

pfam04547
Location:328 → 913

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:68 → 325

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_063286858.1 → XP_063142928.1 anoctamin-2 isoform X1

Related

ENSRNOP00000030034.6, ENSRNOT00000032112.7
XM_039108820.2 → XP_038964748.1 anoctamin-2 isoform X2

Conserved Domains (2) summary

pfam04547
Location:190 → 775

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:19 → 187

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_063286859.1 → XP_063142929.1 anoctamin-2 isoform X3