Pnpla4 patatin like phospholipase domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpla4provided by RGD
Official Full Name: patatin like phospholipase domain containing 4provided by RGD
Primary source: RGD:1562200
See related: EnsemblRapid:ENSRNOG00000026157 AllianceGenome:RGD:1562200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562200
Summary: Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA4 (patatin like phospholipase domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 40.6), Kidney (RPKM 35.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: Xq21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (46200351..46205517, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (42313554..42318451, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (45519406..45522988, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables diolein transacylation activity	ISO Inferred from Sequence Orthology more info
enables mono-olein transacylation activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables retinyl-palmitate esterase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: patatin-like phospholipase domain-containing protein 4

NP_001388110.1

EC 3.1.1.3

EC 3.1.1.4

NP_001388111.1

EC 3.1.1.3

EC 3.1.1.4

NP_001388112.1

EC 3.1.1.3

EC 3.1.1.4

XP_006257030.1

EC 3.1.1.3

EC 3.1.1.4

XP_006257031.1

EC 3.1.1.3

EC 3.1.1.4

XP_008771463.1

EC 3.1.1.3

EC 3.1.1.4

XP_038956156.1

EC 3.1.1.3

EC 3.1.1.4

XP_038956157.1

EC 3.1.1.3

EC 3.1.1.4

XP_063136208.1

EC 3.1.1.3

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401181.1 → NP_001388110.1 patatin-like phospholipase domain-containing protein 4 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

D4A227

Related

ENSRNOP00000100393.1, ENSRNOT00000143064.1
NM_001401182.1 → NP_001388111.1 patatin-like phospholipase domain-containing protein 4 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

D4A227
NM_001401183.1 → NP_001388112.1 patatin-like phospholipase domain-containing protein 4 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

46200351..46205517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100229.2 → XP_038956157.1 patatin-like phospholipase domain-containing protein 4 isoform X2

UniProtKB/TrEMBL

D4A227

Conserved Domains (1) summary

cd07222
Location:12 → 234

Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
XM_006256968.4 → XP_006257030.1 patatin-like phospholipase domain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006257030.1

UniProtKB/TrEMBL

D4A227

Conserved Domains (1) summary

cd07222
Location:5 → 249

Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
XM_008773241.3 → XP_008771463.1 patatin-like phospholipase domain-containing protein 4 isoform X4

See identical proteins and their annotated locations for XP_008771463.1

Conserved Domains (1) summary

cl11396
Location:1 → 175

Patatin_and_cPLA2; Patatins and Phospholipases
XM_063280138.1 → XP_063136208.1 patatin-like phospholipase domain-containing protein 4 isoform X4
XM_039100228.2 → XP_038956156.1 patatin-like phospholipase domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

D4A227

Conserved Domains (1) summary

cd07222
Location:5 → 249

Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4
XM_006256969.5 → XP_006257031.1 patatin-like phospholipase domain-containing protein 4 isoform X3

See identical proteins and their annotated locations for XP_006257031.1

Conserved Domains (1) summary

cl11396
Location:3 → 191

Patatin_and_cPLA2; Patatins and Phospholipases