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    Cers2 ceramide synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310667, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cers2provided by RGD
    Official Full Name
    ceramide synthase 2provided by RGD
    Primary source
    RGD:1310059
    See related
    EnsemblRapid:ENSRNOG00000021138 AllianceGenome:RGD:1310059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lass2
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Involved in several processes, including negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum. Biomarker of sciatic neuropathy. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 637.0), Lung (RPKM 320.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cers2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185579511..185587789)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182890527..182898805)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196487656..196495930)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485650

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC124761

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ceramide synthase 2
    Names
    LAG1 homolog, ceramide synthase 2
    NP_001028872.2
    XP_006232949.1
    XP_006232950.1
    XP_038958282.1
    XP_038958283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033700.2NP_001028872.2  ceramide synthase 2

      See identical proteins and their annotated locations for NP_001028872.2

      Status: VALIDATED

      Source sequence(s)
      BC101876, BI284504, CF110567, CK365108
      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Related
      ENSRNOP00000028699.2, ENSRNOT00000028699.6
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185579511..185587789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232888.4XP_006232950.1  ceramide synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006232950.1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. XM_039102355.2XP_038958283.1  ceramide synthase 2 isoform X1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. XM_039102354.2XP_038958282.1  ceramide synthase 2 isoform X1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    4. XM_006232887.5XP_006232949.1  ceramide synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006232949.1

      UniProtKB/TrEMBL
      A6K2Y5, G3V8V4, Q3T1K1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.