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    Prm2 protamine 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25345, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prm2provided by RGD
    Official Full Name
    protamine 2provided by RGD
    Primary source
    RGD:3409
    See related
    EnsemblRapid:ENSRNOG00000002539 AllianceGenome:RGD:3409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PROTA2
    Summary
    Predicted to enable cadmium ion binding activity and zinc ion binding activity. Predicted to be involved in nucleus organization; sequestering of metal ion; and spermatid development. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human PRM2 (protamine 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1129.4) See more
    Orthologs
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    Genomic context

    See Prm2 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5383208..5383949)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4876285..4877026)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4950484..4950920)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RecQ mediated genome instability 2 Neighboring gene protamine 1 Neighboring gene uncharacterized LOC120095020 Neighboring gene protamine 3 Neighboring gene transition protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadmium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleus organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sequestering of metal ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    NOT located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protamine-2
    Names
    sperm histone P2
    sperm protamine P2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012873.2NP_037005.1  protamine-2

      See identical proteins and their annotated locations for NP_037005.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P11248
      Related
      ENSRNOP00000003450.1, ENSRNOT00000003450.4
      Conserved Domains (1) summary
      pfam00841
      Location:141
      Protamine_P2; Sperm histone P2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      5383208..5383949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)