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    MFSD10 major facilitator superfamily domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 10227, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MFSD10provided by HGNC
    Official Full Name
    major facilitator superfamily domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:16894
    See related
    Ensembl:ENSG00000109736 MIM:610977; AllianceGenome:HGNC:16894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TETRAN; TETTRAN
    Summary
    This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MFSD10 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2930567..2934825, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2929030..2933288, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2932294..2936552, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21189 Neighboring gene nonconserved acetylation island sequence 125 enhancer Neighboring gene SH3 domain binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2821815-2822316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2827676-2828562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2828563-2829448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21193 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2838931-2839928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:2844343-2844854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2863877-2864589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:2864590-2865301 Neighboring gene adducin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876343-2876870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876871-2877396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2923771-2924668 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2924669-2925564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2925565-2926460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2927877-2928392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene NOP14 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. Duyao MP, et al. Hum Mol Genet, 1993 Jun. PMID 8353488
    2. Expression and function of TETRAN, a new type of membrane transporter. Ushijima H, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18638446
    3. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. Mima S, et al. FEBS Lett, 2007 Apr 3. PMID 17362938
    4. Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. Lobo MJ, et al. Commun Biol, 2020 Oct 21. PMID 33087821, Free PMC Article
    5. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tetracycline transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium-independent organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetracycline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 10
    Names
    tetracycline transporter-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001120.5 → NP_001111.3  major facilitator superfamily domain-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_001111.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AL390065, BC001502, BC023537, BI769550, L11669
      Consensus CDS
      CCDS3365.1
      UniProtKB/Swiss-Prot
      Q07706, Q14728
      Related
      ENSP00000332646.4, ENST00000329687.8
      Conserved Domains (1) summary
      pfam07690
      Location:85 → 412
      MFS_1; Major Facilitator Superfamily

    2. NM_001146069.2 → NP_001139541.1  major facilitator superfamily domain-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_001139541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC001502, CN422014
      Consensus CDS
      CCDS3365.1
      UniProtKB/Swiss-Prot
      Q07706, Q14728
      Related
      ENSP00000347619.4, ENST00000355443.9
      Conserved Domains (1) summary
      pfam07690
      Location:85 → 412
      MFS_1; Major Facilitator Superfamily

    3. NM_001363679.2 → NP_001350608.1  major facilitator superfamily domain-containing protein 10 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL390065
      Consensus CDS
      CCDS87203.1
      UniProtKB/TrEMBL
      D6RA47, D6RIZ4
      Related
      ENSP00000423402.1, ENST00000507555.1
      Conserved Domains (1) summary
      cl21472
      Location:90 → 225
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    4. NM_001410703.1 → NP_001397632.1  major facilitator superfamily domain-containing protein 10 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL390065
      Consensus CDS
      CCDS93471.1
      UniProtKB/TrEMBL
      D6RE79
      Related
      ENSP00000426907.1, ENST00000514800.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      2930567..2934825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449490.1 → XP_047305446.1  major facilitator superfamily domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      D6RA47

    2. XM_047449491.1 → XP_047305447.1  major facilitator superfamily domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      D6R9N3
      Related
      ENSP00000423509.1, ENST00000503596.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      2929030..2933288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348717.1 → XP_054204692.1  major facilitator superfamily domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      D6RA47

    2. XM_054348718.1 → XP_054204693.1  major facilitator superfamily domain-containing protein 10 isoform X3

    3. XM_054348719.1 → XP_054204694.1  major facilitator superfamily domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      D6R9N3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14728.1 GenPept UniProtKB/Swiss-Prot:Q14728

    Gene LinkOut

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