TRIB2 tribbles pseudokinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIB2provided by HGNC
Official Full Name: tribbles pseudokinase 2provided by HGNC
Primary source: HGNC:HGNC:30809
See related: Ensembl:ENSG00000071575 MIM:609462; AllianceGenome:HGNC:30809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C5FW; TRB2; GS3955
Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Expression: Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p24.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (12716936..12742734)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (12746001..12771799)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (12857062..12882860)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.
Title: TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.
Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.
Title: Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.
Upregulation of Tribbles decreases body weight and increases sleep duration.
Title: Upregulation of Tribbles decreases body weight and increases sleep duration.
TRIB2 safeguards naive T cell homeostasis during aging.
Title: TRIB2 safeguards naive T cell homeostasis during aging.
Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.
Title: Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.
Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
Title: Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.
Title: Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.
Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF).
Title: Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF).
A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma.
Title: A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma.
TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3beta-beta-Catenin Signaling Axis.
Title: TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3β-β-Catenin Signaling Axis.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS of dental caries patterns in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19140 (e-PCR)
- UniSTS:82499

STS-Z40317 (e-PCR)
- UniSTS:30106

RH12451 (e-PCR)
- UniSTS:4844

WIAF-2088 (e-PCR)
- UniSTS:8430

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables nucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ubiquitin-protein transferase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tribbles homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011644.1 RefSeqGene

Range

5065..30863

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_021643.4 → NP_067675.1 tribbles homolog 2

See identical proteins and their annotated locations for NP_067675.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes a functional protein.

Source sequence(s)

AC009486

Consensus CDS

CCDS1683.1

UniProtKB/Swiss-Prot

B2R851, D6W510, Q92519

Related

ENSP00000155926.4, ENST00000155926.9

Conserved Domains (1) summary

cd14022
Location:67 → 308

PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

RNA

NR_027303.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC009486, AK129973, AK299146, AY245544, D87119

Related

ENST00000381465.2