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    HB-3 homeobox-3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817958, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB-3
    Official Full Name
    homeobox-3
    Primary source
    TAIR:AT2G33880
    Locus tag
    AT2G33880
    See related
    Araport:AT2G33880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homeobox-3; STIMPY; STIP; T1B8.31; T1B8_31; WOX9; WOX9A; WUSCHEL related homeobox 9A; WUSCHEL-RELATED HOMEOBOX 9
    Summary
    Encodes a protein with similarity to WUS type homeodomain protein. Required for meristem growth and development and acts through positive regulation of WUS. Loss of function phenotypes include embryo lethality, hyponastic cotyledons, reduced root development and smaller meristems. Phenotypes can be rescued by addition of sucrose in the growth media. Overexpression can partially rescue the triple mutant cytokinin receptor phenotype suggesting HB-3 is a downstream effector of cytokinin signaling.
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    Genomic context

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    See HB-3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (14341355..14343796, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RAB GTPase homolog A1H Neighboring gene tRNA-Pro Neighboring gene nudix hydrolase homolog 22 Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STIMPY mutants have increased cytokinin sensitivity during dark germination. Skylar A, et al. Plant Signal Behav, 2010 Nov. PMID 21057190, Free PMC Article
    2. Requirement of homeobox gene STIMPY/WOX9 for Arabidopsis meristem growth and maintenance. Wu X, et al. Curr Biol, 2005 Mar 8. PMID 15753038
    3. Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development. Ueda M, et al. Dev Cell, 2011 Feb 15. PMID 21316593
    4. Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development. Wu X, et al. Dev Biol, 2007 Sep 15. PMID 17706632, Free PMC Article
    5. STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings. Skylar A, et al. Development, 2010 Feb. PMID 20110319, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stip mutants show enhanced de-etiolation phenotype in response to cytokinin treatment in the dark, suggesting that STIP may be a negative regulator of cytokinin signaling under this condition.
      Title: STIMPY mutants have increased cytokinin sensitivity during dark germination.
    2. Expression of WOX8 is independent of the axis patterning signal auxin, but, together with the redundant gene WOX9, is activated in the zygote, its basal daughter cell, and the hypophysis by the zinc-finger transcription factor WRKY2.
      Title: Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development.
    3. cytokinin signaling is involved in activation of the homeobox gene STIMPY (STIP or WOX9) expression in meristematic tissues, which is essential for maintaining the meristematic fate
      Title: STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings.
    4. Complete loss of STIP activity results in early embryonic arrest, most likely due to a failure in cell division.
      Title: Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development.
    5. STIMPY (STIP; also called WOX9) is a homeobox gene required for the growth of the vegetative shoot apical meristem, in part by positively regulating WUSCHEL protein expression. [STIMPY] [STIP] [WOX9]
      Title: Requirement of homeobox gene STIMPY/WOX9 for Arabidopsis meristem growth and maintenance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336476.1
    NM_128948.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox-3
    NP_180944.2
    • homeobox-3 (HB-3); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 8 (TAIR:AT5G45980.1); Has 671 Blast hits to 615 proteins in 76 species: Archae - 0; Bacteria - 0; Metazoa - 25; Fungi - 22; Plants - 589; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14341355..14343796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128948.4 → NP_180944.2  homeobox-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180944.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23662, Q6X7J4, Q8GX13
      Conserved Domains (1) summary
      pfam00046
      Location:54 → 114
      Homeobox; Homeobox domain

    2. NM_001336476.1 → NP_001324695.1  homeobox-3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQA8, A0A1P8B0W7, A0A384KQD3
      Conserved Domains (1) summary
      pfam00046
      Location:54 → 114
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6X7J4.1

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