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    ZAT zinc transporter [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZAT
    Official Full Name
    zinc transporter
    Primary source
    TAIR:AT2G46800
    Locus tag
    AT2G46800
    See related
    Araport:AT2G46800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA CATION DIFFUSION FACILITATOR 1; ATCDF1; ATMTP1; F19D11.8; metal tolerance protein 1; MTP1; OVERLY ZINC SENSITIVE 1; OZS1; ZAT1; zinc transporter of Arabidopsis thaliana; ZINC TRANSPORTER OF ARABIDOPSIS THALIANA 1; ZINC TRANSPORTER ZAT
    Summary
    Encodes a member of the zinc transporter (ZAT) and cation diffusion facilitator (CDF) families. It is expressed throughout the plant, especially in dividing, differentiating and expanding cells. The protein is localized to the vacuolar membrane. Mediates Zn ion homeostasis.
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    Genomic context

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    See ZAT in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (19235374..19239577)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene pseudo-response regulator 9 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene photosystem I P subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation. van der Zaal BJ, et al. Plant Physiol, 1999 Mar. PMID 10069843, Free PMC Article
    2. A mutant strain Arabidopsis thaliana that lacks vacuolar membrane zinc transporter MTP1 revealed the latent tolerance to excessive zinc. Kawachi M, et al. Plant Cell Physiol, 2009 Jun. PMID 19433490
    3. Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity. Kawachi M, et al. J Biol Chem, 2008 Mar 28. PMID 18203721, Free PMC Article
    4. Characterization of the histidine-rich loop of Arabidopsis vacuolar membrane zinc transporter AtMTP1 as a sensor of zinc level in the cytosol. Tanaka N, et al. Plant Cell Physiol, 2015 Mar. PMID 25516571
    5. Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation. Desbrosses-Fonrouge AG, et al. FEBS Lett, 2005 Aug 1. PMID 16038907

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest that the His-loop of MTP1 acts as a sensor of cytosolic zinc to maintain an essential level in the cytosol and that the dysfunction of the loop results in an uncontrolled accumulation of zinc in the vacuoles of root cells.
      Title: Characterization of the histidine-rich loop of Arabidopsis vacuolar membrane zinc transporter AtMTP1 as a sensor of zinc level in the cytosol.
    2. MTP1 provides a tolerance mechanism to Zn stress.
      Title: A mutant strain Arabidopsis thaliana that lacks vacuolar membrane zinc transporter MTP1 revealed the latent tolerance to excessive zinc.
    3. AtMTP1 functions as a Zn(2+)/H(+) antiporter in vacuoles and that a histidine-rich region is not essential for zinc transport
      Title: Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity.
    4. The MTP1 protein of Arabidopsis thaliana belongs to a ubiquitous family of transition metal transporters that extrude metal ions from the cytoplasm (MTP1)
      Title: MTP1 mops up excess zinc in Arabidopsis cells.
    5. RNA interference-mediated silencing of AtMTP1 causes Zn hypersensitivity and a reduction in Zn concentrations in vegetative plant tissues [MTP1]
      Title: Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation.
    6. we propose that AtMTP1 is localized in the vacuolar membrane and is involved in sequestration of excess Zn in the cytoplasm into vacuoles to maintain Zn homeostasis.[ATMTP1]
      Title: Zinc transporter of Arabidopsis thaliana AtMTP1 is localized to vacuolar membranes and implicated in zinc homeostasis.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337215.1
    NM_001337217.1
    NM_130246.3
    NM_180128.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular zinc ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular zinc ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within zinc ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    zinc transporter
    NP_001318436.1
    • zinc transporter of Arabidopsis thaliana (ZAT); FUNCTIONS IN: zinc ion transmembrane transporter activity, inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: cellular zinc ion homeostasis, zinc ion transport, response to metal ion; LOCATED IN: vacuolar membrane, plasma membrane, vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: metal tolerance protein A2 (TAIR:AT3G58810.1); Has 17747 Blast hits to 10591 proteins in 2218 species: Archae - 164; Bacteria - 10632; Metazoa - 2900; Fungi - 834; Plants - 528; Viruses - 26; Other Eukaryotes - 2663 (source: NCBI BLink).
    NP_182203.1
    • zinc transporter of Arabidopsis thaliana (ZAT); FUNCTIONS IN: zinc ion transmembrane transporter activity, inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: cellular zinc ion homeostasis, zinc ion transport, response to metal ion; LOCATED IN: vacuolar membrane, plasma membrane, vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: metal tolerance protein A2 (TAIR:AT3G58810.1); Has 17776 Blast hits to 10611 proteins in 2227 species: Archae - 165; Bacteria - 10659; Metazoa - 2900; Fungi - 835; Plants - 528; Viruses - 26; Other Eukaryotes - 2663 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19235374..19239577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337216.1 → NP_001324595.1  zinc transporter [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81036, Q9ZT63
      UniProtKB/TrEMBL
      A0A178VQA0, A0A384KM83, Q0WW73
      Conserved Domains (1) summary
      TIGR01297
      Location:67 → 397
      CDF; cation diffusion facilitator family transporter

    2. NM_001337215.1 → NP_001318436.1  zinc transporter [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81036, Q9ZT63
      UniProtKB/TrEMBL
      A0A178VQA0, A0A384KM83, Q0WW73
      Conserved Domains (1) summary
      TIGR01297
      Location:67 → 397
      CDF; cation diffusion facilitator family transporter

    3. NM_001337217.1 → NP_001324594.1  zinc transporter [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81036, Q9ZT63
      UniProtKB/TrEMBL
      A0A178VQA0, A0A384KM83, Q0WW73
      Conserved Domains (1) summary
      TIGR01297
      Location:67 → 397
      CDF; cation diffusion facilitator family transporter

    4. NM_180128.3 → NP_850459.1  zinc transporter [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81036, Q9ZT63
      UniProtKB/TrEMBL
      A0A178VQA0, A0A384KM83, Q0WW73
      Conserved Domains (1) summary
      TIGR01297
      Location:67 → 397
      CDF; cation diffusion facilitator family transporter

    5. NM_130246.3 → NP_182203.1  zinc transporter [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81036, Q9ZT63
      UniProtKB/TrEMBL
      A0A178VQA0, A0A384KM83, Q0WW73
      Conserved Domains (1) summary
      TIGR01297
      Location:67 → 397
      CDF; cation diffusion facilitator family transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZT63.2

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