GRL transcription activator [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GRL
Official Full Name: transcription activator
Primary source: TAIR:AT2G35110
Locus tag: AT2G35110
See related: Araport:AT2G35110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GNARLED; NAP1; NAPP; NCK-ASSOCIATED PROTEIN 1; T4C15.22; T4C15_22
Summary: Component of the WAVE protein complex which act as activators of ARP2/3 complex involved in actin nucleation. Required for trichome morphogenesis. Mutant displays distorted trichomes, a phenotype that can be phenocopied by treatment of WT plants with actin-interacting drugs. Its ER localization is independent of upstream SPK1 activation signaling and the physical association with the WAVE/SCAR Regulatory complex binding partner SRA1. ER-localized NAP1 has little colocalization with actin and represent the inactive pool of NAP1 in these cell types.
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Genomic context

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See GRL in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 23

Sequence:: Chromosome: 2; NC_003071.7 (14795715..14803971, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repair.
Title: The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repair.
Authors establish that TGNap1 contributes to microtubule-dependent biogenesis, tracking and function of a TGN subset, likely through interaction with Rab6 and YIP4.
Title: TGNap1 is required for microtubule-dependent homeostasis of a subpopulation of the plant trans-Golgi network.
NAP1, a component of the SCAR/WAVE complex, locates to vesicles or puncta that appear upon applied pressure. The majority co-localizes with the autophagosome marker ATG8, and anti-NAP1 identifies autophagosomes in immuno-TEM. Fewer autophagosomes are generated in the NAP1 knockout mutant during starvation stress.
Title: Arabidopsis NAP1 Regulates the Formation of Autophagosomes.
NAP1 localizes to multiple organelles in developing pavement cells and trichomes. The endoplasmic reticulum-associated NAP1 is inactive because it displays little colocalization with the actin network.
Title: The endoplasmic reticulum is a reservoir for WAVE/SCAR regulatory complex signaling in the Arabidopsis leaf.
AtNAP1;1 is a component of a regulatory mechanism that connects cell proliferation to cell growth and expansion during Arabidopsis leaf development.
Title: Developmentally controlled farnesylation modulates AtNAP1;1 function in cell proliferation and cell expansion during Arabidopsis leaf development.
The multiple growth and developmental phenotypes of Atnap and Atpir mutants reveals these proteins are also required for a wider variety of cellular functions in addition to regulating trichome cell growth.
Title: Arabidopsis NAP and PIR regulate actin-based cell morphogenesis and multiple developmental processes.
encodes a putative regulator of the WAVE-HSPC300 complex, NAP125, combined with the phenotypic similarity between arp2/3 and grl mutants, provides evidence that the ARP2/3 complex is indeed regulated by the above mentioned pathway in Arabidopsis [gnarled]
Title: The Arabidopsis GNARLED gene encodes the NAP125 homolog and controls several actin-based cell shape changes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001036408.3

Supported by ESTs:

NM_129064.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin nucleation	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within trichome morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: transcription activator

NP_001031485.1

GNARLED (GRL); CONTAINS InterPro DOMAIN/s: Nck-associated protein 1 (InterPro:IPR019137); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_181056.2

GNARLED (GRL); CONTAINS InterPro DOMAIN/s: Nck-associated protein 1 (InterPro:IPR019137); Has 2387 Blast hits to 741 proteins in 151 species: Archae - 0; Bacteria - 54; Metazoa - 569; Fungi - 142; Plants - 67; Viruses - 0; Other Eukaryotes - 1555 (source: NCBI BLink).