RAD50 DNA repair-recombination protein (RAD50) [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: RAD50
Official Full Name: DNA repair-recombination protein (RAD50)
Primary source: TAIR:AT2G31970
Locus tag: AT2G31970
See related: Araport:AT2G31970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRAD50; DNA REPAIR-RECOMBINATION PROTEIN; F22D22.28; F22D22_28
Summary: Encodes the Arabidopsis RAD50 homologue. It is involved in double strand break repair. Component of the meiotic recombination complex that processes meiotic double-strand-breaks to produce single-stranded DNA ends, which act in the homology search and recombination. Accumulates in the nucleus during meiotic prophase, a process regulated by PHS1.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_128757.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Mre11 complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_565733.1

RAD50; FUNCTIONS IN: zinc ion binding, ATP binding, nuclease activity; INVOLVED IN: DNA repair, double-strand break repair, telomere capping, mitotic recombination, telomere maintenance; LOCATED IN: nucleus, Mre11 complex, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc hook, Rad50 (InterPro:IPR013134), Rad50 zinc hook (InterPro:IPR007517), Recombination/repair protein Rad50 (InterPro:IPR004584); Has 105617 Blast hits to 56308 proteins in 2913 species: Archae - 1820; Bacteria - 19240; Metazoa - 45759; Fungi - 8381; Plants - 4805; Viruses - 470; Other Eukaryotes - 25142 (source: NCBI BLink).